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Both drugs have shown promising results in improving glycemic control and promoting weight loss, but their mechanisms and clinical profiles differ
Clinical trials have demonstrated small mean reductions in systolic blood pressure (typically 3-5 mmHg), which may contribute to overall cardiovascular risk reduction
And perhaps most relevant to this combination, hunger hormones, particularly ghrelin, tend to decrease in ketosis, reinforcing the appetite suppression that semaglutide is already creating through a completely separate pathway
GLP-1RA FAERS analyses (class-level): FAERS analyses across GLP-1 receptor agonists highlight dehydration/volume depletion as an area needing attention and demonstrate sex differences in some adverse event patterns in broader AE categories
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